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Medications

Diroximel fumarate delayed-release capsules

What is this medicine?

DIROXIMEL FUMARATE (dye ROX i mel FUE ma rate) helps to decrease the number of multiple sclerosis relapses in people with relapsing-remitting forms of the disease. It is not a cure.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush, or chew this medicine. Swallow the capsules whole. You can take it with or without food. If it upsets your stomach, take it with food. Do not drink alcohol at the time you take a dose of this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • fever, chills, sore throat

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • signs and symptoms of a serious brain infection like changes in vision, confusion, weakness on one side of the body, loss of balance or coordination, loss of memory, or changes in personality

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • facial flushing

  • nausea

  • stomach pain

  • upset stomach

What may interact with this medicine?

Do not take this medicine with the following medications:

  • dimethyl fumarate

This medicine may also interact with the following medications:

  • alcohol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • immune system problems

  • infection

  • kidney disease

  • liver disease

  • low blood counts, like white cells

  • an unusual or allergic reaction to diroximel fumarate, dimethyl fumarate, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or of they get worse. You may need blood work done while you are taking this medicine.

Taking your medicine with food (avoid high-fat, high-calorie meal or snack) may help reduce flushing. Call your doctor if the flushing bothers you or does not go away.

In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your healthcare professional right away. If you cannot reach your healthcare professional, urgently seek other source of medicial care.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier